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1

Senolytics and senostatics as adjuvant tumour therapy

Short, Susan, Fielder, Edward, Miwa, Satomi, von Zglinicki, Thomas

Journal:

Year:

2019

Language:

english

File:

PDF, 831 KB

english, 2019

2

Oxidative stress shortens telomeres

Thomas von Zglinicki

Journal:

Trends in Biochemical Sciences

Year:

2002

Language:

english

File:

PDF, 88 KB

english, 2002

3

The epigenetic clock and telomere length are independently associated with chronological age and mortality

Marioni, Riccardo E, Harris, Sarah E, Shah, Sonia, McRae, Allan F, von Zglinicki, Thomas, Martin-Ruiz, Carmen, Wray, Naomi R, Visscher, Peter M, Deary, Ian J

Journal:

International Journal of Epidemiology

Year:

2017

Language:

english

File:

PDF, 219 KB

english, 2017

4

Replicative Aging, Telomeres, and Oxidative Stress

GABRIELE SARETZKI, THOMAS VON ZGLINICKI

Journal:

Annals of the New York Academy of Sciences

Year:

2002

Language:

english

File:

PDF, 201 KB

english, 2002

5

A senescent cell bystander effect: senescence-induced senescence

Glyn Nelson, James Wordsworth, Chunfang Wang, Diana Jurk, Conor Lawless, Carmen Martin-Ruiz, Thomas von Zglinicki

Journal:

Year:

2012

Language:

english

File:

PDF, 619 KB

english, 2012

6

Telomeres: Influencing the Rate of Aging

THOMAS VON ZGLINICKI

Journal:

Annals of the New York Academy of Sciences

Year:

1998

Language:

english

File:

PDF, 106 KB

english, 1998

7

Telomere-driven replicative senescence is a stress response

Zglinicki, Thomas von, Petrie, Joanne, Kirkwood, Thomas B.L.

Journal:

Nature Biotechnology

Year:

2003

Language:

english

File:

PDF, 264 KB

english, 2003

8

A DNA damage checkpoint response in telomere-initiated senescence

Fagagna, Fabrizio d'Adda di, Reaper, Philip M., Clay-Farrace, Lorena, Fiegler, Heike, Carr, Philippa, von Zglinicki, Thomas, Saretzki, Gabriele, Carter, Nigel P., Jackson, Stephen P.

Journal:

Year:

2003

Language:

english

File:

PDF, 515 KB

english, 2003

9

Telomere length predicts poststroke mortality, dementia, and cognitive decline

Carmen Martin-Ruiz, Heather O. Dickinson, Barbara Keys, Elise Rowan, Rose Anne Kenny, Thomas Von Zglinicki

Journal:

Annals of Neurology

Year:

2006

Language:

english

File:

PDF, 116 KB

english, 2006

10

Role of Oxidative Stress in Telomere Length Regulation and Replicative Senescence

THOMAS VON ZGLINICKI

Journal:

Annals of the New York Academy of Sciences

Year:

2000

Language:

english

File:

PDF, 2.79 MB

english, 2000

11

Telomere Length As a Marker of Oxidative Stress in Primary Human Fibroblast Cultures

VIOLETA SERRA, TILMAN GRUNE, NICOLLE SITTE, GABRIELE SARETZKI, THOMAS VON ZGLINICKI

Journal:

Annals of the New York Academy of Sciences

Year:

2000

Language:

english

File:

PDF, 1.06 MB

english, 2000

12

DNA damage response and cellular senescence in tissues of aging mice

Chunfang Wang, Diana Jurk, Mandy Maddick, Glyn Nelson, Carmen Martin-Ruiz, Thomas Von Zglinicki

Journal:

Year:

2009

Language:

english

File:

PDF, 1.34 MB

english, 2009

13

Cellular senescence: unravelling complexity

João F. Passos, Cedric Simillion, Jennifer Hallinan, Anil Wipat, Thomas von Zglinicki

Journal:

Year:

2009

Language:

english

File:

PDF, 281 KB

english, 2009

14

The epigenetic clock and telomere length are independently associated with chronological age and mortality

Marioni, Riccardo E, Harris, Sarah E, Shah, Sonia, McRae, Allan F, von Zglinicki, Thomas, Martin-Ruiz, Carmen, Wray, Naomi R, Visscher, Peter M, Deary, Ian J

Journal:

International Journal of Epidemiology

Year:

2016

Language:

english

File:

PDF, 478 KB

english, 2016

15

Telomere shortening in human fibroblasts is not dependent on the size of the telomeric-3′-overhang

Barbara Keys, Violeta Serra, Gabriele Saretzki, Thomas Von Zglinicki

Journal:

Year:

2004

Language:

english

File:

PDF, 265 KB

english, 2004

16

Ribozyme-mediated telomerase inhibition induces immediate cell loss but not telomere shortening in ovarian cancer cells

Saretzki, Gabriele, Ludwig, Antje, von Zglinicki, Thomas, Runnebaum, Ingo B

Journal:

Cancer Gene Therapy

Year:

2001

Language:

english

File:

PDF, 322 KB

english, 2001

17

Mitochondrial dysfunction in osteoarthritis is associated with down-regulation of superoxide dismutase 2

Gavriilidis, Christos, Miwa, Satomi, von Zglinicki, Thomas, Taylor, Robert W., Young, David A.

Journal:

Arthritis & Rheumatism

Year:

2013

Language:

english

File:

PDF, 308 KB

english, 2013

18

Dynamic Modelling of Pathways to Cellular Senescence Reveals Strategies for Targeted Interventions

Dalle Pezze, Piero, Nelson, Glyn, Otten, Elsje G., Korolchuk, Viktor I., Kirkwood, Thomas B. L., von Zglinicki, Thomas, Shanley, Daryl P., Rzhetsky, Andrey

Journal:

PLoS Computational Biology

Year:

2014

Language:

english

File:

PDF, 6.36 MB

english, 2014

19

Extended lifespan and long telomeres in rectal fibroblasts from late-onset ulcerative colitis patients

Getliffe, Katherine M., Martin Ruiz, Carmen, Passos, Jo??o F., von Zglinicki, Thomas, Nwokolo, Chuka U.

Journal:

European Journal of Gastroenterology & Hepatology

Year:

2006

Language:

english

File:

PDF, 136 KB

english, 2006

20

Grip strength and inflammatory biomarker profiles in very old adults

Granic, Antoneta, Davies, Karen, Martin-Ruiz, Carmen, Jagger, Carol, Kirkwood, Thomas B.L., von Zglinicki, Thomas, Aihie Sayer, Avan

Journal:

Year:

2017

Language:

english

File:

PDF, 136 KB

english, 2017

21

The Relationship between the Aging- and Photo-Dependent T414G Mitochondrial DNA Mutation with Cellular Senescence and Reactive Oxygen Species Production in Cultured Skin Fibroblasts

Birket, Matthew J, Passos, João F, von Zglinicki, Thomas, Birch-Machin, Mark A

Journal:

The Journal of Investigative Dermatology

Year:

2008

Language:

english

File:

PDF, 467 KB

english, 2008

22

TRF2 overexpression diminishes repair of telomeric single-strand breaks and accelerates telomere shortening in human fibroblasts

Torsten Richter, Gabriele Saretzki, Glyn Nelson, Mathias Melcher, Sharon Olijslagers, Thomas von Zglinicki

Journal:

Mechanisms of Ageing and Development

Year:

2007

Language:

english

File:

PDF, 598 KB

english, 2007

23

Protein oxidation and degradation during proliferative senescence of human MRC-5 fibroblasts

Nicolle Sitte, Katrin Merker, Thomas von Zglinicki, Tilman Grune

Journal:

Free Radical Biology and Medicine

Year:

2000

Language:

english

File:

PDF, 433 KB

english, 2000

24

Human fibroblasts in vitro senesce with a donor-specific telomere length

Violeta Serra, Thomas von Zglinicki

Journal:

Year:

2002

Language:

english

File:

PDF, 239 KB

english, 2002

25

Frailty and mortality are not influenced by mitochondrial DNA haplotypes in the very old

Collerton, Joanna, Ashok, Deepthi, Martin-Ruiz, Carmen, Pyle, Angela, Hudson, Gavin, Yadegarfar, Mohammad, Davies, Karen, Jagger, Carol, von Zglinicki, Thomas, Kirkwood, Thomas B.L., Chinnery, Patrick

Journal:

Neurobiology of Aging

Year:

2013

Language:

english

File:

PDF, 159 KB

english, 2013

26

Health and disease in 85 year olds: baseline findings from the Newcastle 85+ cohort study

Joanna Collerton, Karen Davies, Carol Jagger, Andrew Kingston, John Bond, Martin P Eccles, Louise A Robinson, Carmen Martin-Ruiz, Thomas von Zglinicki, Oliver F W James and Thomas B L Kirkwood

Journal:

Year:

2010

Language:

english

File:

PDF, 332 KB

english, 2010

27

Comparison of senescence-associated miRNAs in primary skin and lung fibroblasts

Holly, Alice C., Grellscheid, Sushma, van de Walle, Pieter, Dolan, David, Pilling, Luke C., Daniels, Darren J., von Zglinicki, Thomas, Ferrucci, Luigi, Melzer, David, Harries, Lorna W.

Journal:

Year:

2015

Language:

english

File:

PDF, 343 KB

english, 2015

28

The Ageing Brain: Effects on DNA Repair and DNA Methylation in Mice

Langie, Sabine, Cameron, Kerry, Ficz, Gabriella, Oxley, David, Tomaszewski, Bartłomiej, Gorniak, Joanna, Maas, Lou, Godschalk, Roger, van Schooten, Frederik, Reik, Wolf, von Zglinicki, Thomas, Mathers

Journal:

Year:

2017

Language:

english

File:

PDF, 2.11 MB

english, 2017

29

Sublethal whole-body irradiation causes progressive premature frailty in mice

Fielder, Edward, Weigand, Melanie, Agneessens, Julien, Griffin, Brigid, Parker, Craig, Miwa, Satomi, von Zglinicki, Thomas

Journal:

Mechanisms of Ageing and Development

Year:

2019

Language:

english

File:

PDF, 1.32 MB

english, 2019

30

A continuous correlation between oxidative stress and telomere shortening in fibroblasts

Torsten Richter, Thomas von Zglinicki

Journal:

Experimental Gerontology

Year:

2007

Language:

english

File:

PDF, 207 KB

english, 2007

31

Acquisition of aberrant DNA methylation is associated with frailty in the very old: findings from the Newcastle 85+ Study

Collerton, Joanna, Gautrey, Hannah E., van Otterdijk, Sanne D., Davies, Karen, Martin-Ruiz, Carmen, von Zglinicki, Thomas, Kirkwood, Thomas B. L., Jagger, Carol, Mathers, John C., Strathdee, Gordon

Journal:

Year:

2014

Language:

english

File:

PDF, 409 KB

english, 2014

32

Childhood Growth, IQ and Education as Predictors of White Blood Cell Telomere Length at Age 49–51 Years: The Newcastle Thousand Families Study

Pearce, Mark S., Mann, Kay D., Martin-Ruiz, Carmen, Parker, Louise, White, Martin, von Zglinicki, Thomas, Adams, Jean, Magdinier, Frédérique

Journal:

Year:

2012

Language:

english

File:

PDF, 84 KB

english, 2012

33

A Stochastic Step Model of Replicative Senescence Explains ROS Production Rate in Ageing Cell Populations

Lawless, Conor, Jurk, Diana, Gillespie, Colin S., Shanley, Daryl, Saretzki, Gabriele, von Zglinicki, Thomas, Passos, João F., Selvarajoo, Kumar

Journal:

Year:

2012

Language:

english

File:

PDF, 315 KB

english, 2012

34

Capability and dependency in the Newcastle 85+ cohort study. Projections of future care needs

Carol Jagger, Joanna C Collerton, Karen Davies, Andrew Kingston, Louise A Robinson, Martin P Eccles, Thomas von Zglinicki, Carmen Martin-Ruiz, Oliver FW James, Tom BL Kirkwood, John Bond

Journal:

Year:

2011

Language:

english

File:

PDF, 291 KB

english, 2011

35

BJ fibroblasts display high antioxidant capacity and slow telomere shortening independent of hTERT transfection

Mario Lorenz, Gabriele Saretzki, Nicolle Sitte, Susanne Metzkow, Thomas von Zglinicki

Journal:

Free Radical Biology and Medicine

Year:

2001

Language:

english

File:

PDF, 274 KB

english, 2001

36

Accumulation of single-strand breaks is the major cause of telomere shortening in human fibroblasts

Thomas von Zglinicki, Rita Pilger, Nicolle Sitte

Journal:

Free Radical Biology and Medicine

Year:

2000

Language:

english

File:

PDF, 520 KB

english, 2000

37

Low abundance of the matrix arm of complex I of mice liver mitochondria predicts longevity

Miwa, Satomi, Jow, Howsun, Treumann, Achim, von Zglinicki, Thomas

Journal:

Biochimica et Biophysica Acta (BBA) - Bioenergetics

Year:

2012

Language:

english

File:

PDF, 53 KB

english, 2012

38

Quantitative Röntgenmikroanalyse biologischer Ultradünnschnitte mit Aluminium-Kohle-Aufdampfschichten als Standards

Zglinicki, Thomas Von

Journal:

Acta Histochemica

Year:

1983

Language:

german

File:

PDF, 491 KB

german, 1983

39

Standardization and quality controls for the methylated DNA immunoprecipitation technique

Lisanti, Sofia, von Zglinicki, Thomas, Mathers, John C.

Journal:

Year:

2012

Language:

english

File:

PDF, 2.25 MB

english, 2012

40

Mitochondria and ageing: winning and losing in the numbers game

João F. Passos, Thomas von Zglinicki, Thomas B.L. Kirkwood

Journal:

Year:

2007

Language:

english

File:

PDF, 166 KB

english, 2007

41

Mitochondria, telomeres and cell senescence

João F. Passos, Thomas von Zglinicki

Journal:

Experimental Gerontology

Year:

2005

Language:

english

File:

PDF, 165 KB

english, 2005

42

The measurement of water distribution in frozen specimens

Thomas von Zglinicki

Journal:

Journal of Microscopy

Year:

1991

Language:

english

File:

PDF, 1.15 MB

english, 1991

43

DNA damage foci in mitosis are devoid of 53BP1

Nelson, Glyn, Buhmann, Matthias, von Zglinicki, Thomas

Journal:

Year:

2009

Language:

english

File:

PDF, 1.13 MB

english, 2009

44

MitoQ counteracts telomere shortening and elongates lifespan of fibroblasts under mild oxidative stress

Gabriele Saretzki, Michael P. Murphy, Thomas Von Zglinicki

Journal:

Year:

2003

Language:

english

File:

PDF, 193 KB

english, 2003

45

Telomere length in white blood cells is not associated with morbidity or mortality in the oldest old: a population-based study

Carmen M. Martin-Ruiz, Jacobijn Gussekloo, Diana van Heemst, Thomas von Zglinicki, Rudi G. J. Westendorp

Journal:

Year:

2005

Language:

english

File:

PDF, 91 KB

english, 2005

46

Short Telomeres in Patients with Vascular Dementia: An Indicator of Low Antioxidative Capacity and a Possible Risk Factor?

von Zglinicki, Thomas, Serra, Violeta, Lorenz, Mario, Saretzki, Gabriele, Lenzen-Groβimlighaus, Romana, Geβner, Reinhard, Risch, Angela, Steinhagen-Thiessen, Elisabeth

Journal:

Laboratory Investigation

Year:

2000

Language:

english

File:

PDF, 286 KB

english, 2000

47

Replicative senescence and the art of counting

Thomas Von Zglinicki

Journal:

Experimental Gerontology

Year:

2003

Language:

english

File:

PDF, 124 KB

english, 2003

48

Mitochondrial dysfunction is a possible cause of accelerated senescence of mesothelial cells exposed to high glucose

Krzysztof Ksiazek, João F. Passos, Sharon Olijslagers, Thomas von Zglinicki

Journal:

Biochemical and Biophysical Research Communications

Year:

2008

Language:

english

File:

PDF, 605 KB

english, 2008

49

Frailty and the role of inflammation, immunosenescence and cellular ageing in the very old: Cross-sectional findings from the Newcastle 85+ Study

Joanna Collerton, Carmen Martin-Ruiz, Karen Davies, Catharien M. Hilkens, John Isaacs, Claire Kolenda, Craig Parker, Michael Dunn, Michael Catt, Carol Jagger, Thomas von Zglinicki, Thomas B.L. Kirkwoo

Journal:

Mechanisms of Ageing and Development

Year:

2012

Language:

english

File:

PDF, 434 KB

english, 2012

50

Mild Hyperoxia Shortens Telomeres and Inhibits Proliferation of Fibroblasts: A Model for Senescence?

Thomas von Zglinicki, Gabriele Saretzki, Wolf Döcke, Christian Lotze

Journal:

Experimental Cell Research

Year:

1995

File:

PDF, 756 KB

1995

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